Higher plasma level of small dense low-density lipoprotein cholesterol in ST-segment-elevation myocardial infarction patients with plaque rupture

Abstract Aim The aim of this study was to compare small dense low-density lipoprotein cholesterol (sd-LDL-c) and various lipid markers between patients exhibiting plaque rupture (PR) in the culprit lesions evaluated by optical coherence tomography (OCT) imaging those without PR ST-segment elevation myocardial infarction (STEMI) patients. Methods We studied consecutive 60 de novo with STEMI who underwent pre-intervention OCT. defined as a containing cavity that had overlying residual fibrous caps. Plasma sd-LDL-c measured directly homogeneous assay at time primary percutaneous coronary intervention. Results were classified into (n=40, 66.7%) or non-PR (n=20, 33.3%). There no significant differences (LDL-c), non-high-density (non-HDL-c) pre-admission statin therapy two groups (135.1±38.0 mg/dL vs 129.2±43.8 mg/dL; p=0.35, 157.1±37.4 143.0±37.7 p=0.24, 15.0% 20.0%; p=0.93). However, level significantly higher than (44.0±18.1 28.0±9.3 p=0.0005). On multiple logistic regression analysis, an independent predictor (odds ratio, 1.14 per 1 p=0.0063). Conclusion Sd-LDL-c associated lesion STEMI. Funding Acknowledgement Type funding sources: None.